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The principal cytochrome P450 isoenzyme associated appears to become CYP2E1, with CYP1A2 and CYP3A4 as supplemental pathways. Approximately eighty five% of an oral dose appears in the urine inside 24 hrs of administration, most because the glucuronide conjugate, with small amounts of other conjugates and unchanged drug [see OVERDOSAGE] for toxicity